Link to WebSite: http://www.theylab.org
Our main goal is to identify novel strategies to treat and prevent human disease. In our lab. we utilize a multidisciplinary approach to explore how G protein coupled receptors (GPRCs), the largest family of signaling receptors and a major therapeutic target, function in real-time. Results from our work will provide alternative opportunities to manipulate these receptors in vivo.
Our main areas of research are:
GPCR (Funded by NIH-NIDA)
Our work is focused on understanding how receptor trafficking can control its signaling. Specifically we are looking at the Mu opioid receptor and the Cannabinoid receptors (CNR1-CNR2).
We have identified a mechanism by which receptors control beta-arrestin mediated signaling. This mechanisms can be acutely modulated to specifically control signaling, providing an alternative way to affect GPCR function. We are currently testing if this approach can be utilized in other GPRCs in vitro and in vivo utilizing zebrafish.
BK Channels ( Funded by NIH-NIAAA/RISE)
In close colaboration with the Treistman lab. we investigate the physiology and trafficking of the BK channel and its subunits during acute and chronic regulation by ethanol exposure in neurons.
Cell Biology of Coral endosimbiosis (Funded by NSF-CREST)
One of the goals of our work is to develop a microscopic imaging system that will allow us to simultaneously image symbiont photochemical capacity and intracellular physicochemical parameters to better understand coral-algal symbioses. We also investigate the molecular events involved during coral bleaching and test different approaches to mitigate symbiont release.
Jacqueline Flores-Otero (Now faculty at UPR)
Garrett E. Seale
Carlos Jose Vazquez Delgado
Debra Kendall (UConn)
Ken Mackie (IU)