The Institute of Neurobiology is an interdisciplinary, interdepartmental research center of the Medical Sciences Campus of the University of Puerto Rico. Its members carry out basic research in Neuroscience, with particular emphasis on the use of simple systems to understand basic mechanisms of nervous system function and development.

Located in Old San Juan, the Institute overlooks the Atlantic Ocean and El Morro, the fortress which guards San Juan bay. There are currently 14 full-time faculty members who carry out research and graduate teaching at the Institute. Their research interests range from the development of insect synapses to the anatomy of retinal projections in mammals.

Graduate students carrying out research at the Institute are enrolled in Ph.D. and M.Sc. programs in the Medical Sciences Campus and in the Department of Biology, UPR. Students from other institutions are also welcome to apply for the Tropical Neuroethology course, held during the summer.

The Institute houses laboratories equipped for electrophysiology, biochemistry, molecular biology and histology, including confocal and electron microscopy. There are 3 guest suites and a kitchen, accommodating up to 12 visitors.

The Institute of Neurobiology hosted the Puerto Rico Neuroscience Conference in 1999.